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Titanocenes as Anticancer Agents: Recent Insights

Název česky Titanoceny jako protinádorová léčiva: Nejnovější poznatky
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SKOUPILOVÁ Hana HRSTKA Roman BARTOŠÍK Martin

Rok publikování 2017
Druh Článek v odborném periodiku
Časopis / Zdroj Medicinal Chemistry
Fakulta / Pracoviště MU

Přírodovědecká fakulta

Citace
www http://www.eurekaselect.com/148762/article
Doi http://dx.doi.org/10.2174/1573406412666161228113650
Klíčová slova Chemotherapy, cisplatin, clinical trials, organometallic compounds, titanocene compounds, titanocene dichloride.
Popis Background: Enormous success of antitumor agent cisplatin initiated interest in other organometallic complexes. A subclass of organometallic compounds termed metallocenes, characterized by a transition metal central atom (M) bound to cyclopentadienide (Cp-/[C5H5]-) ligands with the basic formula Cp2M, has gained increasing interest as promising anticancer agents. Objectives: This review summarizes the progress in the development of organometallic titaniumbased compounds focusing primarily on the evaluation of their cytotoxic activity and mechanism of action in relation to potential utilization as anticancer drugs. Results: Metallocenes bearing titanium as central atom were sorted according to their structure and modifications and their anticancer activity is further discussed. Conclusion: Titanocenes represent family of promising compounds exerting cytostatic activity. We suggest that their application not only as separate agents, but also in combination with newly developed carriers, e.g. nanomaterials, may lead to improvement of their delivery into tumor cells and following utilization in cancer treatment.

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