Informace o publikaci

Single cell analysis revealed a coexistence of NOTCH1 and TP53 mutations within the same cancer cells in chronic lymphocytic leukaemia patients

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KANTOROVÁ Barbara MALČÍKOVÁ Jitka STRÁNSKÁ Kamila BORSKY Marek PLEVOVÁ Karla SMARDOVA Jana RADOVÁ Lenka TOM Nikola TRBUSEK Martin DIVISKOVA Eva FRANCOVA SKUHROVA Hana NAVRKALOVÁ Veronika DOUBEK Michael BRYCHTOVA Yvona MAYER Jiří POSPÍŠILOVÁ Šárka

Rok publikování 2017
Druh Článek v odborném periodiku
Časopis / Zdroj British journal of haematology
Fakulta / Pracoviště MU

Středoevropský technologický institut

Citace
www http://onlinelibrary.wiley.com/doi/10.1111/bjh.14176/abstract;jsessionid=CCC32E2E63D96F860D239E95FFE3908B.f02t03
Doi http://dx.doi.org/10.1111/bjh.14176
Obor Onkologie a hematologie
Klíčová slova EVOLUTION; HETEROGENEITY; CLL
Popis The clinical course in chronic lymphocytic leukaemia (CLL) patients is diverse, reflecting the heterogeneous biological background of this disease (Guieze & Wu, 2015). Among reported defects, mutations in NOTCH1 and TP53 genes represent potent CLL progression drivers and contribute to disease chemo-refractoriness (Fabbri et al, 2011; Malcikova et al, 2015). Although parallel occurrence of NOTCH1 mutations and TP53 defects has been noted in CLL patients (Weissmann et al, 2013; Stilgenbauer et al, 2014), the clonal composition of these coexisting aberrations has not been yet studied. To clarify this phenomenon, we examined CLL patients with concurrently detected hotspot NOTCH1 and TP53 mutations using single cell analysis.
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