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TUSC3: functional duality of a cancer gene

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VAŠÍČKOVÁ Kateřina HORÁK Peter VAŇHARA Petr

Rok publikování 2018
Druh Článek v odborném periodiku
Časopis / Zdroj Cellular and Molecular Life Sciences
Fakulta / Pracoviště MU

Lékařská fakulta

Citace
www https://link.springer.com/article/10.1007%2Fs00018-017-2660-4
Doi http://dx.doi.org/10.1007/s00018-017-2660-4
Obor Genetika a molekulární biologie
Klíčová slova TUSC3; Cancer; Tumor suppressor; Oncogene; Endoplasmic reticulum; N-Glycosylation; Immunoediting
Popis Two decades ago, following a systematic screening of LOH regions on chromosome 8p22, TUSC3 has been identified as a candidate tumor suppressor gene in ovarian, prostate and pancreatic cancers. Since then, a growing body of evidence documented its clinical importance in various other types of cancers, and first initial insights into its molecular function and phenotypic effects have been gained, though the precise role of TUSC3 in different cancers remains unclear. As a part of the oligosaccharyltransferase complex, TUSC3 localizes to the endoplasmic reticulum and functions in final steps of N-glycosylation of proteins, while its loss evokes the unfolded protein response. We are still trying to figure out how this mechanistic function is reconcilable with its varied effects on cancer promotion. In this review, we focus on cancer-related effects of TUSC3 and envisage a possible role of TUSC3 beyond endoplasmic reticulum
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