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Reanalysis of Chinese Treponema pallidum samples: all Chinese samples cluster with SS14-like group of syphilis-causing treponemes

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STROUHAL Michal OPPELT Jan MIKALOVÁ Lenka ARORA Natasha NIESELT Kay GONZÁLEZ-CANDELAS Fernando ŠMAJS David

Rok publikování 2018
Druh Článek v odborném periodiku
Časopis / Zdroj BMC Research Notes
Fakulta / Pracoviště MU

Lékařská fakulta

Citace
www https://bmcresnotes.biomedcentral.com/articles/10.1186/s13104-017-3106-7
Doi http://dx.doi.org/10.1186/s13104-017-3106-7
Klíčová slova Genome sequencing; Phylogenetic analysis; Single nucleotide variant; SyphilisTreponema pallidum
Popis Treponema pallidum subsp. pallidum (TPA) is the causative agent of syphilis. Genetic analyses of TPA reference strains and human clinical isolates have revealed two genetically distinct groups of syphilis-causing treponemes, called Nichols-like and SS14-like groups. So far, no genetic intermediates, i.e. strains containing a mixed pattern of Nichols-like and SS14-like genomic sequences, have been identified. Recently, Sun et al. (Oncotarget 2016. https://doi.org/10.18632/oncotarget.10154) described a new “phylogenetic group” (called Lineage 2) among Chinese TPA strains. This lineage exhibited a “mosaic genomic structure” of Nichols-like and SS14-like lineages.
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