Informace o publikaci

INTERACTION OF INTRAMOLECULAR G-QUADRUPLEX DNA STRUCTURES WITH SELECTED ALKALOIDS

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VIDO Marek JAROŠOVÁ Petra TÁBORSKÝ Petr PEŠ Ondřej

Rok publikování 2018
Druh Konferenční abstrakty
Fakulta / Pracoviště MU

Lékařská fakulta

Citace
Popis G-quadruplex DNA (G4) has been known to be involved in many physiological processes in the cell e.g., in the promoter regions of oncogenes or in the human telomeric region. Because of their supposed role in cancer, G4 are often studied as targets for anti-cancer drugs. Natural and/or synthetic compounds, which are able to selectively bind these structures, have been intensively tested by means of molecular spectrometry, circular dichroism, equilibrium dialysis, and mass spectrometry. Compounds may interact with G4 by several mechanisms with various affinities. An approach to study a great number of potential effective compounds relies on combination of methods when relatively fast; however, imprecise mass spectrometry was used to preselect compounds, which were then subjected to more precise techniques studying G4 in a solution.
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