Informace o publikaci

SEMIQUANTITATIVE ASSESSMENT OF DISHEVELLED-3 PHOSPHORYLATION STATUS BY MASS SPECTROMETRY

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HANÁKOVÁ Kateřina POTĚŠIL David BERNATÍK Ondřej ČERVENKA Igor RÁDSETOULAL Matěj BRYJA Vítězslav ZDRÁHAL Zbyněk

Rok publikování 2018
Druh Článek v odborném periodiku
Časopis / Zdroj HUNGARIAN JOURNAL OF INDUSTRY AND CHEMISTRY
Fakulta / Pracoviště MU

Středoevropský technologický institut

Citace
Doi http://dx.doi.org/10.1515/hjic-2018-0002
Klíčová slova phosphorylation; Dishevelled 3; mass spectrometry; CK1 epsilon; NEK2
Popis The focus of this paper is the human Dishevelled 3 protein (hDvl3), an essential component of the Wnt signalling pathway that contributes to their regulation. Mass spectrometry-based analysis of hDvl3 phosphorylations induced by eight associated kinases was performed revealing several dozens of phosphorylation sites. The main outcome of this study was the description of Dvl phosphorylation "patterns" induced by individual kinases.
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