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NECROTISING SARCOID GRANULOMATOSIS. A RARE GRANULOMATOUS DISEASE

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DOUBKOVÁ Martina HAUSNEROVÁ Jitka VÝŠKA Ondřej RICHTER Svatopluk MERTA Zdeněk

Druh Článek v odborném periodiku
Časopis / Zdroj Sarcoidosis Vasculitis and Diffuse Lung Diseases
Fakulta / Pracoviště MU

Lékařská fakulta

Citace
Klíčová slova differential diagnosis; histopathological diagnosis; necrotising sarcoid granulomatosis
Popis Introduction: Necrotizing sarcoid granulomatosis (NSG) is a very rare disease of unknown etiology characterized by sarcoid-like granulomas, vasculitis and necrosis in pulmonary and extrapulmonary localizations. Case report: We describe a case of a 34-year-old Caucasian male with fever, pleural pain, and nodular pulmonary opacities on chest radiograph. Histological examination of the lung tissue confirmed NSG. Diagnostically, infectious causes, vasculitis, and malignancy were excluded. A tendency to partial regression was observed, without the need for corticosteroid treatment. Conclusion: NSG is a rare disease which must be distinguished from other systemic diseases including vasculitides. The key to diagnosis, emphasized in our paper, is the histopathological finding. The course of NSG is similar to sarcoidosis. Corticosteroids are considered the treatment of choice, but the disease exhibits a tendency towards spontaneous regression.