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Haloalkane Dehalogenases From Marine Organisms

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KUNKA Antonín DAMBORSKÝ Jiří PROKOP Zbyněk

Rok publikování 2018
Druh Článek v odborném periodiku
Časopis / Zdroj MARINE ENZYMES AND SPECIALIZED METABOLISM, PT B
Fakulta / Pracoviště MU

Přírodovědecká fakulta

Citace
www https://loschmidt.chemi.muni.cz/peg/category/publications/#2018
Doi http://dx.doi.org/10.1016/bs.mie.2018.03.005
Klíčová slova BIOCHEMICAL-CHARACTERIZATION; GAMMA-HEXACHLOROCYCLOHEXANE; BRADYRHIZOBIUM-JAPONICUM; DEGRADING BACTERIUM; EXPERIMENTAL-DESIGN; COLORIMETRIC ASSAY; PROTEIN STABILITY; ACCESS TUNNELS; STEADY-STATE; GEN. NOV.
Popis Haloalkane dehalogenases degrade halogenated compounds to corresponding alcohols by a hydrolytic mechanism. These enzymes are being intensively investigated as model systems in experimental and in silico studies of enzyme mechanism and evolution, but also hold importance as useful biocatalysts for a number of biotechnological applications. Haloalkane dehalogenases originate from various organisms including bacteria (degraders, symbionts, or pathogens), eukaryotes, and archaea. Several members of this enzyme family have been found in marine organisms. The marine environment represents a good source of enzymes with novel properties, because of its diverse living conditions. A number of novel dehalogenases isolated from marine environments show interesting characteristics such as high activity, unusually broad substrate specificity, stability, or selectivity. In this chapter, the overview of haloalkane dehalogenases from marine organisms is presented and their characteristics are summarized together with an overview of the methods for their identification and biochemical characterization.
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