Informace o publikaci

Lymphoproliferation, immunodeficiency and early-onset inflammatory bowel disease associated with a novel mutation in Caspase 8

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KANDEROVA V. GROMBIŘÍKOVÁ Hana ZENTSOVA I. RÉBLOVÁ Kamila KLOCPERK A. FEJTKOVA M. BLOOMFIELD M. RAVCUKOVA B. KALINA T. FREIBERGER Tomáš SEDIVA A.

Druh Článek v odborném periodiku (nerecenzovaný)
Fakulta / Pracoviště MU

Středoevropský technologický institut

Citace
Popis Caspase-8 is a member of the aspartate-specific cysteine protease family that is typically synthetized as an inactive zymogen and activated upon an appropriate stimulus. Caspase-8 plays an essential role in apoptotic signal transduction from the death receptor. Recruitment of procaspase-8 into the death signaling complex leads to its dimerization, autoproteolytic cleavage and formation of a highly active heterotetramer. Caspase-8 subsequently activates caspase-3, thereby initiating the proteolytic pathway, and ultimately resulting in the apoptotic disassembly of the cell.1 Additionally, caspase-8 is also essential for various immune processes, such as lymphocyte activation, inflammasome regulation and cytokine production
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