Informace o publikaci

Sulfate Source and Its Role in the Development of Colitis



Rok publikování 2019
Druh Kapitola v knize
Fakulta / Pracoviště MU

Přírodovědecká fakulta

Popis Inflammatory bowel disease (IBD), including ulcerative colitis (UC), is a complex multifactorial disease of unknown etiology. Intestinal sulfate-reducing bacteria (SRB), especially Desuflovibrio genus are often found in the intestines and feces of people and animals with IBD. One of the main roles in the development of UC among other factors can also be the species of this genus. These bacteria use sulfate as a terminal electron acceptor and organic compounds as an electron donor in their metabolisms. This fact leads us to the conclusion that sulfate present in the daily diet plays an important role in the development of bowel disease. Sulfate is present mainly in the following food commodities: i) some breads, soya flour, dried fruits, brassicas, and sausages; ii) as well as some beers, ciders, and wines. These data indicate that sulfate intake is highly dependent on diet. Literature data indicates that sulfate level present in diet among people living in more developed countries consume over 16.6 mmole of sulfate per day. It should be noted the role of sulfite present in food since it can also be consumed by SRB. The complexity of sulfate metabolism can be overviewed by data that focuses on the intestinal environment containing different concentrations of hydrogen sulfide produced by SRB. According to the fact mentioned above, this chapter is dealing with issues concerning sulfate present in different food commodities and the intestinal environment affecting mainly SRB. These issues are explained by literature data indicating the role of sulfate in the intestines of animals, including humans. The data present in this chapter can be used to better explain of IBD and improve therapeutic strategies.
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