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HIC1 Expression Distinguishes Intestinal Carcinomas Sensitive to Chemotherapy

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JANECKOVA Lucie KOLAR Michal SVEC Jiri LANIKOVA Lucie POSPÍCHALOVÁ Vendula BALOGHOVA Nikol VOJTECHOVA Martina SLONCOVA Eva STRNAD Hynek KORINEK Vladimir

Rok publikování 2016
Druh Článek v odborném periodiku
Časopis / Zdroj TRANSLATIONAL ONCOLOGY
Fakulta / Pracoviště MU

Přírodovědecká fakulta

Citace
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Doi http://dx.doi.org/10.1016/j.tranon.2016.01.005
Klíčová slova Apoptosis; Bnip3L; caspase-12; hair follicles; PCR arrays
Popis Neoplastic growth is frequently associated with genomic DNA methylation that causes transcriptional silencing of tumor suppressor genes. We used a collection of colorectal polyps and carcinomas in combination with bioinformatics analysis of large datasets to study the expression and methylation of Hypermethylated in cancer 1 (HIC1), a tumor suppressor gene inactivated in many neoplasms. In premalignant stages, HIC1 expression was decreased, and the decrease was linked to methylation of a specific region in the HIC1 locus. However, in carcinomas, the HIC1 expression was variable and, in some specimens, comparable to healthy tissue. Importantly, high HIC1 production distinguished a specific type of chemotherapy-responsive tumors.