Risk assessment of EDCs in Europe based on human biomonitoring data

• Autoři: SARIGIANNIS D.; KARAKITSIOS S.; GOTTI A.; KUMAR V.; SCHUHMACHER M.; BROCHOT C.; CREPET A.; SCHERINGER Martin; DOMINGUEZ ROMERO Elena; BESSEMS J.; BAKEN K.; HORVAT M.; TRATNIK J.
• Rok publikování: 2019
• Druh: Konferenční abstrakty
• Fakulta / Pracoviště MU: Přírodovědecká fakulta
• Popis: A major advantage of human biomonitoring (HBM) data is that they provide an integrated overview of the body burden to xenobiotics that an individual is exposed to. However, quantification of exposure based on HBM data poses significant challenges that are worth facing, given the opportunities that HBM provides in terms of informing and effectively supporting risk assessment. Based on the above, the aim of this within the HBM4EU project was to derive EU-wide external exposure estimates starting from HBM data and to derive and risk characterization ratio (RCR) by comparing these estimates with existing regulatory thresholds. For the reconstruction of exposure the INTEGRA computational platform was properly parameterised for the compounds of interest, namely bisphenol-A (BPA), phthalates (DEHP, DiNP and DnBP) and DINCH, emerging flame retardants (TCEP) and Perfluorinated compounds (PFOA and PFOS).