Informace o publikaci

Conducting composite films based on chitosan or sodium hyaluronate. Properties and cytocompatibility with human induced pluripotent stem cells

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JASENSKÁ Daniela KAŠPÁRKOVÁ Věra RADASZKIEWICZ Katarzyna Anna CAPÁKOVÁ Zdenka PACHERNÍK Jiří TRCHOVÁ Miroslava MINAŘÍK Antonín VAJĎÁK Ján BÁRTA Tomáš STEJSKAL Jaroslav LEHOCKÝ Marián TRUONG Thanh Huong MOUČKA Robert HUMPOLÍČEK Petr

Rok publikování 2021
Druh Článek v odborném periodiku
Časopis / Zdroj Carbohydrate Polymers
Fakulta / Pracoviště MU

Přírodovědecká fakulta

Citace
www https://doi.org/10.1016/j.carbpol.2020.117244
Doi http://dx.doi.org/10.1016/j.carbpol.2020.117244
Klíčová slova Polyaniline; Polysacharides; Conducting composites; Human induced pluripotent stem cells
Popis Novel composite films combining biocompatible polysaccharides with conducting polyaniline (PANI) were prepared via the in-situ polymerization of aniline hydrochloride in the presence of sodium hyaluronate (SH) or chitosan (CH). The composite films possess very good cytocompatibility in terms of adhesion and proliferation of two lines of human induced pluripotent stem cells (hiPSC). Moreover, the cardiomyogenesis and even formation of beating clusters were successfully induced on the films. The proportion of formed cardiomyocytes demonstrated excellent properties of composites for tissue engineering of stimuli-responsive tissues. The testing also demonstrated antibacterial activity of the films against E. coli and PANI-SH was able to reduce bacterial growth from 2 x 10(5) to < 1 cfu cm(-2). Physicochemical characterization revealed that the presence of polysaccharides did not notably influence conductivities of the composites being similar to 1 and similar to 2 S cm(-1) for PANI-SH and PANI-CH respectively; however, in comparison with neat PANI, it modified their topography making the films smoother with mean surface roughness of 4 (PANI-SH) and 14 nm (PANI-CH). The combination of conductivity, antibacterial activity and mainly cytocompatibility with hiPSC opens wide application potential of these polysaccharide-based composites.
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