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Hepatotoxicity of the anionic surfactant linear alkylbenzene sulphonate (LAS) in bullfrog tadpoles

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FRANCO-BELUSSI Lilian JONES-COSTA Monica SALLA Raquel Fernanda SANTOS SOUZA Bruno Fernando PINTO VIDAL Felipe Augusto OLIVEIRA Cristiane Ronchi SILVA-ZACARIN Elaine Cristina Mathias ABDALLA Fabio Camargo DUARTE Iolanda Cristina Silveir DE OLIVEIRA Classius

Rok publikování 2021
Druh Článek v odborném periodiku
Časopis / Zdroj Chemosphere
Fakulta / Pracoviště MU

Přírodovědecká fakulta

Citace
www https://www.sciencedirect.com/science/article/pii/S0045653520332112?via%3Dihub
Doi http://dx.doi.org/10.1016/j.chemosphere.2020.129014
Klíčová slova Surfactants; Sodium dodecylbenzene sulfonate; Hepatic melanomacrophages; Hemosiderin; Immune cells; Hepatocytes; Morphometry
Popis The liver of anurans play an important role in metabolism, including detoxification, the biotransformation of molecules, and the storage of metabolites. Surfactants are part of domestic and industrial effluents. The effects of linear alkylbenzene sulfonate (LAS) on anuran liver remain unknown, however, some studies have evaluated the effects of LAS on the skin, gills, heart, testes, and liver of fishes. Here, we tested the hypothesis that LAS is hepatotoxic, promoting morphometric alterations in hepatocytes along with inflammation in the tissue, altering hepatic catabolism. We evaluated the effects of a LAS concentration that is considered environmentally safe in Brazilian inland waters on the liver of Lithobates catesbeianus tadpoles, including studies on morphology, morphometry, immunology, and metabolism. LAS exposure promoted enlargement of liver sinusoids and vacuolization of hepatocytes. Exposure to LAS also increased the area of mast cells and melanomacrophages (MMs). Additionally, LAS exposure increased hemosiderin inside MMs, suggesting alterations in the catabolism and storage of iron. Hepatocyte size increased after exposure to LAS, suggesting cytotoxic effects. Integrative analyses (i.e., morphometric, metabolic, and immunological) demonstrated hepatotoxic effects of LAS. These types of studies are key to understanding the negative effects of these substances on tadpole health, as these liver alterations impair anuran homeostasis.

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