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Insights into the molecular targets and emerging pharmacotherapeutic interventions for nonalcoholic fatty liver disease

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NEGI Chander Kant BABICA Pavel BAJARD ÉP.ESNER Lola Murielle DOBROVOLNÁ Julie TARANTINO Giovanni

Rok publikování 2022
Druh Článek v odborném periodiku
Časopis / Zdroj Metabolism: Clinical and Experimental
Fakulta / Pracoviště MU

Přírodovědecká fakulta

Citace
www https://www.sciencedirect.com/science/article/pii/S0026049521002250?via%3Dihub
Doi http://dx.doi.org/10.1016/j.metabol.2021.154925
Klíčová slova Nonalcoholic fatty liver disease (NAFLD); Nonalcoholic steatohepatitis (NASH); Drug therapy; Clinical trials; Novel targets
Popis Nonalcoholic fatty liver disease (NAFLD) is the most common form of chronic liver disease worldwide. With no Food and Drug Administration approved drugs, current treatment options include dietary restrictions and lifestyle modification. NAFLD is closely associated with metabolic disorders such as obesity, type 2 diabetes, and dyslipidemia. Hence, clinically various pharmacological approaches using existing drugs such as antidiabetic, anti-obesity, antioxidants, and cytoprotective agents have been considered in the management of NAFLD and nonalcoholic steatohepatitis (NASH). However, several pharmacological therapies aiming to alleviate NAFLD-NASH are currently being examined at various phases of clinical trials. Emerging data from these studies with drugs targeting diverse molecular mechanisms show promising outcomes. This review summarizes the current understanding of the pathogenic mechanisms of NAFLD and provides an insight into the pharmacological targets and emerging therapeutics with specific interventional mechanisms. In addition, we also discuss the importance and utility of new approach methodologies and regulatory perspectives for NAFLD-NASH drug development.
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