Respiratory Viruses in Patients With Hematological Malignancy in Boreal Autumn/Winter 2023-2024: EPICOVIDEHA-EPIFLUEHA Report

• Autoři: SALMANTON-GARCIA Jon; MARCHESI Francesco; NAVRATIL Milan; PIUKOVICS Klara; ILARIA del Principe Maria; CRISCUOLO Marianna; BILGIN Yavuz M; FRACCHIOLLA Nicola S; VENA Antonio; ROMANO Alessandra; FALCES-ROMERO Iker; SGHERZA Nicola; HERAS-FERNANDO Inmaculada; BIERNAT Monika M; PETZER Verena; ZAK Pavel; WEINBERGEROVA Barbora; SAMARKOS Michail; ERBEN Nurettin; JENS van Praet; LOPEZ-GARCIA Alberto; LABRADOR Jorge; LAHMER Tobias; DRGONA Lubos; MERELLI Maria; CUCCARO Annarosa; MARTIN-PEREZ Sonia; DAVILA-VALLS Julio; FARINA Francesca; CATTANEO Chiara; PINCZES Laszlo Imre; MAGYARI Ferenc; ESPIGADO Ildefonso; BUQUICCHIO Caterina; VINH Donald C; STOMA Igor; CERNAN Martin; PREZIOSO Lucia; PAPA Mario Virgilio; PLANTEFEVE Gaetan; KHEDR Reham Abdelaziz; BATINIC Josip; MAGLIANO Gabriele; ERDEM Simge; KHOSTELIDI Sofya; COLOVIC Natasha; NAPPI Davide; GARCIA-RAMIREZ Patricia; GORA Jakub; CALLEJAS-CHARAVIA Marta; TLUSTY Jedrzej; BAKKER Martijn; WOJTYNIAK Elwira; ANTIC Darko; MAGDZIAK Agnieszka; DARGENIO Michelina; IDRIZOVIC Larisa; PANTIC Nikola; STOJANOSKI Zlate; EISA Noha; OTASEVIC Vladimir; MARCHETTI Monia; MACKENZIE Erica; GARCIA-VIDAL Carolina; AUJAYEB Avinash; ALMASARI Ahlam; MIRANDA-CASTILLO Carolina; GAVRIILAKI Eleni; COPPOLA Nicola; BUSCA Alessandro; ADZIC-VUKICEVIC Tatjana; SCHOENLEIN Martin; HERSBY Ditte Stampe; GRAEFE Stefanie K; GLENTHOJ Andreas; AIELLO Tommaso Francesco; CVETANOSKI Milche; MITROVIC Mirjana; CERCHIONE Claudio; PRIN Romane; VARRICCHIO Gina; ARELLANO Elena; CORDOBA Raul; MAYER Jiří; VISEK Benjamin; WOLF Dominik; ANASTASOPOULOU Amalia N; DELIA Mario; MUSTO Pellegrino; LEOTTA Dario; BAVASTRO Martina; LIMONGELLI Alessandro; SCIUME Mariarita; LUKAS van den Ven; FIANCHI Luana; BRUNETTI Sara Caterina; DROZD-SOKOLOWSKA Joanna; DABROWSKA-IWANICKA Anna; CORNELY Oliver A; PAGANO Livio
• Rok publikování: 2025
• Druh: Článek v odborném periodiku
• Časopis / Zdroj: American Journal of Hematology
• Fakulta / Pracoviště MU: Lékařská fakulta
• www: https://onlinelibrary.wiley.com/doi/10.1002/ajh.27565
• Doi: http://dx.doi.org/10.1002/ajh.27565
• Klíčová slova: antiviral therapy; community-acquired respiratory viral infection; hematological malignancy; secondary infection; vaccine coverage
• Popis: Community-acquired respiratory viral infections (CARV) significantly impact patients with hematological malignancies (HM), leading to high morbidity and mortality. However, large-scale, real-world data on CARV in these patients is limited. This study analyzed data from the EPICOVIDEHA-EPIFLUEHA registry, focusing on patients with HM diagnosed with CARV during the 2023-2024 autumn-winter season. The study assessed epidemiology, clinical characteristics, risk factors, and outcomes. The study examined 1312 patients with HM diagnosed with CARV during the 2023-2024 autumn-winter season. Of these, 59.5% required hospitalization, with 13.5% needing ICU admission. The overall mortality rate was 10.6%, varying by virus: parainfluenza (21.3%), influenza (8.8%), metapneumovirus (7.1%), RSV (5.9%), or SARS-CoV-2 (5.0%). Poor outcomes were significantly associated with smoking history, severe lymphopenia, secondary bacterial infections, and ICU admission. This study highlights the severe risk CARV poses to patients with HM, especially those undergoing active treatment. The high rates of hospitalization and mortality stress the need for better prevention, early diagnosis, and targeted therapies. Given the severe outcomes with certain viruses like parainfluenza, tailored strategies are crucial to improving patient outcomes in future CARV seasons.