Informace o publikaci

CT-derived adipose tissue characteristics and TAVI all-cause mortality and complications: a systematic review

Autoři	PEKAŘ Matej BRANNY Piotr JIRAVSKÝ Otakar SPACEK Radim MOHR Jan Alexander RANIC Ivan JIRAVSKA GODULA Bogna CESNAKOVA KONECNA Alica KANTOR Marek HECKO Jan NEUWIRTH Radek SKNOURIL Libor NOVÁK Jan
Rok publikování	2025
Druh	Článek v odborném periodiku
Časopis / Zdroj	European Journal of Medical Research
Fakulta / Pracoviště MU	Lékařská fakulta
Citace
www	https://link.springer.com/article/10.1186/s40001-025-02587-3
Doi	https://doi.org/10.1186/s40001-025-02587-3
Klíčová slova	TAVI outcomes; Adipose tissue parameters; CT-derived body composition; Visceral fat; Subcutaneous fat; Risk stratification
Popis	Transcatheter Aortic Valve Implantation (TAVI) has revolutionized severe aortic stenosis treatment, but risk stratification remains challenging. This systematic review examined the association between computed tomography (CT)-derived adipose tissue parameters and TAVI outcomes. We searched major databases for studies on visceral (VAT), subcutaneous (SAT), and intramuscular (IMAT) adipose tissue parameters and post-TAVI outcomes. Fourteen studies (9692 patients) were included. Higher SAT area/volume was consistently associated with better survival (5 studies, HR range: 0.83-2.77, p < 0.05). Lower SAT and VAT density also correlated with better survival (5 and 4 studies, respectively, HR range: 1.31-1.46, p < 0.05). VAT area showed mixed results. A VAT:SAT ratio < 1 was associated with better cardiovascular outcomes in one study. Lower IMAT index correlated with shorter hospital stays in a single study. This review reveals complex relationships between adipose tissue parameters and TAVI outcomes. Lower adipose tissue density and higher subcutaneous adiposity were most consistently associated with better outcomes. These findings suggest that detailed analysis of adipose tissue characteristics may enhance risk stratification in TAVI candidates.