Informace o publikaci

Proton beam therapy for mediastinal Hodgkin lymphoma: A prospective study of clinical efficacy and safety

Autoři	DEDECKOVA Katerina ANDRLIK Michal MOCIKOVA Heidi KALISKA Lucia ZAPLETALOVA Simona KUBES Jiri AL-HAMAMI Sarah CUTTER David J NTENTAS Georgios VONDRACEK Vladimir ONDROVA Barbora MARKOVA Jana GAHEROVA L'ubica MOHAMMADOVA Lekaa PROCHAZKA Vit MICHALKA Jozef SYKOROVA Alice DURAS Juraj KOREN Jan NAVRATIL Matej VAREJKOVA Michaela DOLEZAL Tomas PRAUSOVA Jana
Rok publikování	2025
Druh	Článek v odborném periodiku
Časopis / Zdroj	RADIOTHERAPY AND ONCOLOGY
Fakulta / Pracoviště MU	Lékařská fakulta
Citace
www	https://www.sciencedirect.com/science/article/pii/S0167814025002269?via%3Dihub
Doi	https://doi.org/10.1016/j.radonc.2025.110931
Klíčová slova	Radiation oncology; Proton beam radiotherapy; Mediastinal Hodgkin lymphoma; Pencil beam scanning; Deep inspiration breath hold
Popis	Background: Proton beam therapy using pencil beam scanning is an advanced radiotherapy technique that utilises proton beams to precisely target tumours. It is known for its enhanced ability in sparing healthy tissue and potentially reducing toxicity. Clinical experience with pencil beam scanning in the treatment of mediastinal Hodgkin lymphoma remains limited. Patients and methods: This study aimed to evaluate the toxicity and outcomes of a prospectively observed cohort. A total of 162 patients were irradiated between May 2013 and December 2020, with a median age of 32 years (range: 18.4-79.2) and followed up until April 2024. The median applied dose was 30 GyE (range: 20-40). Deep inspiration breath hold was used in 146 patients to enhance targeting precision. Results: The disease-free survival, overall survival and local control rates were 95.1 %, 98.8 % and 98.8 %, respectively. The median follow-up was 59.1 months (range: 4-120.1). The most common acute toxicities observed were oesophageal and skin toxicity. Grade 1 oesophageal mucositis occurred in 76 patients (47 %), grade 2 in 16 patients (10 %). Dermatitis of grade 1 and 2 was observed in 65 (40 %) and 4 (3 %) patients respectively. Grade 1 pulmonary toxicity presented in 8 patients (4.9 %), and grade 2 in one patient (0.6 %). The most predominant late toxicity was grade 2 hypothyroidism in 37 patients (23 %). Three patients (1.8 %) underwent coronary interventions during follow-up, and one patient was diagnosed with hepatocellular carcinoma 3 months post-RT. No unexpected acute or late toxicities were observed.