Informace o publikaci

Design specifications for biomedical virtual twins in engineered adoptive cellular immunotherapies

Autoři	WEIRAUCH Ulrike KREUZ Markus BIRKENBIHL Colin ALB Miriam QUARANTA Maria CALZONE Laurence OROZCO-RUIZ Sophia BINDER Stefanie FISCHER Luise CLAVREUL Solene MAGURI Morine FERLE Maximilian RADE Michael AZARIAS Guillaume HYDREN Jay R JAMÁRIK Jakub SCHWARZ Daniel SEBESTYEN Zsolt KUBALL Jurgen POPP Georg ANTOINE Chloe KNOCKAERT Manon SCHOEDER Clara T FANDREI David SANGES Carmen RADVILAS Vaclovas GAGELMANN Nico RUECKERT Markus PENACK Olaf FRICKE Stephan SCHMIDT Andreas WARD Carol STEINBEISSER Carl JEAN-MARC Van Gyseghem NIARAKIS Anna GARDERET Laurent HUDECEK Michael NEUMUTH Thomas PLATZBECKER Uwe KOEHL Ulrike DEMLOVÁ Regina KREMER Andreas FRANKE Stefan FROEHLICH Holger MERZ Maximilian REICHE Kristin
Rok publikování	2025
Druh	Recenzovaný odborný článek
Časopis / Zdroj	NPJ DIGITAL MEDICINE
Fakulta / Pracoviště MU	Lékařská fakulta
Citace
www	https://www.nature.com/articles/s41746-025-01809-6
Doi	https://doi.org/10.1038/s41746-025-01809-6
Klíčová slova	biomedical virtual twins; engineered adoptive cellular immunotherapies
Popis	In (immune)oncology, virtual twins (VTs) offer patient-individual decision support. Nevertheless, current VTs do not incorporate the unique properties of engineered adoptive cellular immunotherapies (eACIs). Here, we outline the minimal design specifications for VTs for engineered ACIs (eACI-VTs) to model the complex interplay between cell product and patient physiology. We motivate utilizing VTs in eACIs to provide decision support and reflect on how eACI-VTs can support the widespread use of eACIs.