Informace o publikaci

Phenogenomic resources immortalized in a panel of wild-derived strains of five species of house mice

Autoři	PIALEK Jaroslav DUREJE Ludovit HIADLOVSKA Zuzana KREISINGER Jakub AGHOVA Tatiana BRYJOVA Anna CIZKOVA Dagmar GOUY de Bellocq Joelle HEJLOVA Helena JANOTOVA Katerina MARTINCOVA Iva ORTH Annie PIALKOVA Jana POSPISILOVA Iva ROUSKOVA Ludmila BIMOVA Barbora Voslajerova PFEIFLE Christine TAUTZ Diethard BONHOMME Francois FOREJT Jiri MACHOLÁN Miloš KLUSÁČKOVÁ Pavla
Rok publikování	2025
Druh	Recenzovaný odborný článek
Časopis / Zdroj	Nature Scientific Reports
Fakulta / Pracoviště MU	Přírodovědecká fakulta
Citace
www	https://doi.org/10.1038/s41598-025-86505-x https://doi.org/10.5061/dryad.r7sqv9skn
Doi	https://doi.org/10.1038/s41598-025-86505-x
Klíčová slova	lleles; Animals; Animals; Wild; DNA Copy Number Variations; DNA; Mitochondrial; Female; Genetic Variation; Histone-Lysine N-Methyltransferase; Male; Mice; Phenotype; Species Specificity
Přiložené soubory	2547760.pdf
Popis	The house mouse, Mus musculus, is a widely used animal model in biomedical research, with classical laboratory strains (CLS) being the most frequently employed. However, the limited genetic variability in CLS hinders their applicability in evolutionary studies. Wild-derived strains (WDS), on the other hand, provide a suitable resource for such investigations. This study quantifies genetic and phenotypic data of 101 WDS representing 5 species, 3 subspecies, and 8 natural Y consomic strains and compares them with CLS. Genetic variability was estimated using whole mtDNA sequences, the Prdm9 gene, and copy number variation at two sex chromosome-linked genes. WDS exhibit a large natural variation with up to 2173 polymorphic sites in mitogenomes, whereas CLS display 92 sites. Moreover, while CLS have two Prdm9 alleles, WDS harbour 46 different alleles. Although CLS resemble M. m. domesticus and M. m. musculus WDS, they differ from them in 10 and 14 out of 16 phenotypic traits, respectively. The results suggest that WDS can be a useful tool in evolutionary and biomedical studies with great potential for medical applications.