Informace o publikaci
Colloid cysts of the third ventricle show consistent expression of PAX8 but lack other features of thyroid, müllerian or intestinal differentiation
| Autoři | |
|---|---|
| Rok publikování | 2026 |
| Druh | Článek v odborném periodiku |
| Časopis / Zdroj | Human pathology |
| Fakulta / Pracoviště MU | |
| Citace | |
| www | https://www.sciencedirect.com/science/article/pii/S0046817725003156 |
| Doi | https://doi.org/10.1016/j.humpath.2025.106028 |
| Klíčová slova | Colloid cyst of the 3rd ventricle; Rathke cleft cyst; Neurenteric cyst; Craniopharyngioma PAX8; SOX17; TTF1; Cadherin 17 |
| Popis | Colloid cyst of the 3rd ventricle (CC) is an unusual cystic lesion of uncertain histogenesis, occurring exclusively in the 3rd ventricle close to the foramen Monro. In the past, its pathogenic relationship to neurenteric cyst (NEC) of central nervous system or Rathke cleft cyst (RCC) has been suggested. Thus, we evaluated expression of selected tissue-specific transcription factors and other proteins to assess its putative origin. Tissue samples of 15 CCs (8 females and 7 males, mean age 46.7 years), 7 RCCs (7 females, mean age 45.6 years), 8 neurenteric cysts (5 females and 2 males, mean age 42.1 years, including 1 recurrent case), and 10 craniopharyngiomas (2 papillary and 8 adamantinomatous) were included. Immunohistochemical detections of PAX8 with C-terminus specific antibody, TTF1, SOX17, and cadherin 17 were performed in all the samples. The immunoreactivity was scored based on extent (0 %; <10 %; 10-50 %; >50 %) and intensity (weak, moderate, strong). All 15 cases of CCs were PAX8 positive (moderate to strong expression in >50 % in 13/15 cases), while no RCC, NEC or craniopharyngioma showed PAX8 immunoreactivity. Rare PAX8-positive cells were also observed in single cells of 50 % (3/6) of the choroid plexuses. No expression of TTF1 or SOX17 was detected in any of the cases and weak cadherin 17 expression was seen in scattered cells (<10 %) of one CC and RCC. Colloid cysts of the 3rd ventricle are consistently PAX8-positive, while they lack signs of thyroid, m & uuml;llerian or enteric differentiation. Furthermore, PAX8 can be used to distinguish CC from NEC, RCC, and craniopharyngiomas. |
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