Informace o publikaci

PEDIATRIC ALK-NEGATIVE ANAPLASTIC LARGE CELL LYMPHOMA GENETICALLY DIFFERS FROM THE ADULT COUNTERPART

Autoři	JAMES Emily R SALMERON-VILLALOBOS Julia COLMENERO Ariadna FRAUENFELD Leonie ANDRES Mara VERDU Jamie GARCIA Noelia SIMONITSCH-KLUPP Ingrid ATTARBASCHI Andishe BACON Chris M BURKE G A Amos LOCKHART Brian DUCRAY Stephen P CHEN Zi TZIONI Maria-Myrsini MATTHEWS Jamie D STEEL Christopher PILLON Marta MUSSOLIN Lara PERVEZ Shahid PILLAI Vinodh ŠTĚRBA Jaroslav KRENOVA Zdenka VEENING Margreet A WROBEL Grazyna WERNER Jana KNORR Fabian OSCHLIES Ilske KLAPPER Wolfram WOESSMANN Wilhelm BALAGUE Olga SALAVERRIA Itziar TURNER Suzanne Dawn
Rok publikování	2025
Druh	Recenzovaný odborný článek
Časopis / Zdroj	Leukemia Research
Fakulta / Pracoviště MU	Lékařská fakulta
Citace
www	https://www.sciencedirect.com/science/article/pii/S0145212625004692?pes=vor&utm_source=clarivate&getft_integrator=clarivate
Doi	https://doi.org/10.1016/j.leukres.2025.108025
Klíčová slova	PEDIATRIC; ALK-NEGATIVE ANAPLASTIC; LARGE CELL LYMPHOMA
Popis	Background: Systemic anaplastic lymphoma kinase-negative anaplastic large cell lymphoma (ALK- ALCL) predominantly affects adults, whereas pediatric and young adult ALK- ALCL cases are rare. For adult ALK- ALCL, studies have uncovered recurrent rearrangements of DUSP22 (31%) and VAV1 (16%) and, at lower frequencies, ROS1, TYK2, FRK, and TP63 rearrangements as well as JAK1 and/or STAT3 activating mutations1,2. However, none of these studies included pediatric or young adult patients. Objectives: The aim of this study was to characterize the genetic landscape of pediatric and young adult systemic ALK- ALCL and primary cutaneous CD30-positive T-cell lymphoproliferative disorders (pcCD30+ LPD).