Informace o publikaci
POTENTIALLY INAPPROPRIATE PRESCRIBING AMONG OLDER ADULTS IN SLOVAKIA: A POPULATION-BASED STUDY OF PRE-PANDEMIC TRENDS
| Autoři | |
|---|---|
| Rok publikování | 2026 |
| Druh | Článek v odborném periodiku |
| Časopis / Zdroj | ACTA POLONIAE PHARMACEUTICA |
| Fakulta / Pracoviště MU | |
| Citace | |
| www | https://www.ptfarm.pl/download/?file=File%2FActa_Poloniae%2F2025%2F5%2F847.pdf |
| Doi | https://doi.org/10.32383/appdr/215551 |
| Klíčová slova | potentially inappropriate medication; older adults; outpatients; drug use; Slovakia; polypharmacy |
| Popis | Potentially inappropriate medications (PIMs) pose significant risks to older adults. This study analyzed trends in PIM prescribing among Slovak older adults before the COVID-19 pandemic. A retrospective population-based study was conducted using data from the National Health Information Centre database from 2015 to 2018. All outpatients aged >= 65 years receiving >= 1 prescribed medication per year were included. PIMs were identified using the European list of potentially inappropriate medications (EU(7)-PIM list). Consumption was evaluated based on the number of prescribed medicine packages and defined daily doses (DDD/1000 inhabitants/day). Descriptive statistics included frequencies, percentages, and means +/- SD. Temporal trends were analyzed using linear regression and chi-square tests. The study population increased from 725,730 treated patients in 2015 to 794,104 in 2018, representing 92.6% to 90.8% of the total population aged >= 65 years. A total of 7,923,497 PIM packages were dispensed during the study period. The proportion of PIMs among total medications increased from 19.1% to 20.4%. The top 10 PIMs accounted for 61.6% of all inappropriate medications, with pantoprazole (14.8%), alprazolam (11.7%), and moxonidine (6.0%) being the most frequent. Significant temporal trends included increases in apixaban (+123.3%, p = 0.003), rivaroxaban (+92.4%, p = 0.029), and zolpidem (+42.0%, p = 0.008), while verapamil (-23.1%, p = 0.001) and diclofenac (-15.0%, p < 0.001) decreased. The prevalence of potentially inappropriate prescribing among older adults in Slovakia is substantial. These pre-pandemic data provide essential information for evaluating the impact of COVID-19 on geriatric prescribing practices. The findings highlight the need for targeted interventions to optimize medication use, particularly focusing on proton pump inhibitors, benzodiazepines, and cardiovascular medications. |
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