Informace o publikaci
Astrocyte-induced dynamics of a pyramidal cell with a dendrite-connected astrocyte
| Autoři | |
|---|---|
| Rok publikování | 2026 |
| Druh | Recenzovaný odborný článek |
| Časopis / Zdroj | JOURNAL OF COMPUTATIONAL NEUROSCIENCE |
| Fakulta / Pracoviště MU | |
| Citace | |
| www | https://link.springer.com/article/10.1007/s10827-026-00924-x |
| Doi | https://doi.org/10.1007/s10827-026-00924-x |
| Klíčová slova | Pyramidal cell; Astrocyte; Epileptiform activity; Pinsky-Rinzel model; Li-Rinzel-type model |
| Přiložené soubory | |
| Popis | Previous multi-parameter bifurcation analyses of the Pinsky-Rinzel neuron model have elucidated a mechanistic explanation for the complex interplay between the membrane potentials of CA3 pyramidal cells and their intracellular dendritic calcium levels. By coupling this neuron model with the Li-Rinzel-type model of astrocytic Ca2+ dynamics, we demonstrate how astrocytic calcium signaling dynamically modulates neuronal activity. We present a classification of potential dynamical transients, including transitions to epileptiform activity. Furthermore, we identify a bidirectional role of astrocytes where they may not only facilitate the emergence of high-frequency oscillations associated with epileptiform activity but may also contribute to their attenuation. Additionally, we propose a mechanism that prolongs the bursting duration of pyramidal cells, which may be associated with synaptic plasticity. Finally, we validate our modeling framework by replicating experimental paradigms that link astrocytic Ca2+ dynamics with neuronal hyperexcitability, demonstrating that astrocytes may drive neurons toward the seizure threshold. These findings enhance our understanding of integrated neural circuit dynamics, particularly the role of neuron-astrocyte interactions in modulating bursting behavior, neural signaling, and their potential contribution to both the generation and suppression of epileptiform ripples. |
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