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DNA interactions of antitumor cisplatin analogs containing enantiomeric amine ligands

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MALINA Jaroslav HOFR Ctirad MARESCA Lucciana NATILE Giovanni BRABEC Viktor

Druh Článek v odborném periodiku
Časopis / Zdroj Biophysical Journal
Fakulta / Pracoviště MU

Přírodovědecká fakulta

Citace
Obor Biofyzika
Popis Modifications of natural DNA and synthetic oligodeoxyribonucleotide duplexes in a cell-free medium by analogues of antitumor cisplatin containing enantiomeric amine ligands, such as cis-[PtCl2(RR-DAB)] and cis-[PtCl2(SS-DAB)] (DAB = 2,3-diaminobutane), were studied by various methods of molecular biophysics and biophysical chemistry. The major differences resulting from the modification of DNA by the two enantiomers consist in the thermodynamical destabilization and conformational distortions induced in DNA by the 1,2-d(GpG) intrastrand cross-link. It has been suggested that these differences are associated with a different biological activity of the two enantiomers observed previously.

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