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An association of three polymorphisms in the gene coding for endothelin-1 (ET-1) in essential hypertension

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VAŠKŮ Anna IZAKOVIČOVÁ HOLLÁ Lydie TSCHÖPLOVÁ Svatava MUŽÍK Jan SOUČEK Miroslav VÁCHA Jiří

Rok publikování 2000
Druh Článek v odborném periodiku
Časopis / Zdroj Atherosclerosis
Fakulta / Pracoviště MU

Lékařská fakulta

Citace
Obor Kardiovaskulární nemoci včetně kardiochirurgie
Popis Four hundred of Caucasian (Czech) normotensive (normotension was confirmed by 24-h ambulatory blood pressure monitoring) and hypertensive subjects of the age of 45-55 years were compared in three ET-1 gene (6p21.3) polymorphisms CA/CT dinucleotide repeat in Z-area, I/D (-4A/-3A) polymorphism in the promoter and Taq1 (G8002A) polymorphism in the intron 4 detected by PCR methods.The allelic length of CA/CT dinucleotide repeat polymorphism was significantly higher in hypertensive subjects (P=0.032). Allelic concurrence of I/D promoter polymorphism and Taq1 polymorphism was significantly different (P=0.008) in hypertensive vs.normotensive women (not in men). Linkage disequilibria between CA/CT and Taq polymorphisms were found both in hypertensive (P=0.008) and normotensive (P=0.02) subjects. Complex interaction among alleles inside the gene coding for ET-1 gene could participate in pathogenesis of essential hypertension.
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