Informace o publikaci
v-Jun and v-Fos proteins induce dedifferentiation of v-myb-transformed monoblasts
| Autoři | |
|---|---|
| Rok publikování | 2001 |
| Druh | Článek ve sborníku |
| Konference | The 17th annual meeting on oncogenes |
| Fakulta / Pracoviště MU | |
| Citace | |
| Obor | Genetika a molekulární biologie |
| Klíčová slova | Fos |
| Popis | The fos/jun proto-oncogenes encode for proteins which are components of the AP-1 transcription complex that includes several Fos related and Jun related proteins. The AP-1 was shown to play multiple roles in functional development of hematopoietic precursor cells to mature blood cells. To gain insights into the role of fos/jun in leukemogenicity, we expressed v-fos and v-jun in the line of chicken monoblasts BM2. We found that either v-fos or v-jun-expressing BM2 cells exhibit signs of dedifferentiation. This suggests that oncogenic forms of Jun adn Fos proteins can further enforce v-Myb transformation. |
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