Informace o publikaci
In silico mutagenesis and docking study of RSL lectin
| Název česky | Vyzkum In silico mutagenezy a dockovania RSL lectinu |
|---|---|
| Autoři | |
| Rok publikování | 2010 |
| Druh | Konferenční abstrakty |
| Fakulta / Pracoviště MU | |
| Citace | |
| Popis | The gram-negative bacterium Ralstonia solanacearum produces a potent L-fucose binding lectin (RSL). This work is focused on in silico mutagenesis, docking of fucose and fucosylated oligosaccharides in RSL lectin. Binding energy pattern of various saccharides was investigated by a series of docking simulations. Docking experiments were performed using the software AutoDock 3, AutoDock Vina, DOCK v.6.2 and ICM Dock. Performance of various docking programs will be discussed with respect to binding energy of those saccharides measured from SPR experiment. |
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