Informace o publikaci

High perioperative level of oxidative stress as a prognostic tool for identifying patients with a high risk of recurrence of head and neck squamous cell carcinoma

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SALZMAN Richard PÁCAL Lukáš KAŇKOVÁ Kateřina TOMANDL Josef HORÁKOVÁ Zuzana TOTHOVA Eva KOSTŘICA Rom

Rok publikování 2010
Druh Článek v odborném periodiku
Časopis / Zdroj International Journal of Clinical Oncology
Fakulta / Pracoviště MU

Lékařská fakulta

Citace
www DOI 10.1007/s10147-010-0108-z
Obor Onkologie a hematologie
Klíčová slova Glutathione peroxidase; Head and neck cancer; Malondialdehyde; oxidative stress; prognostic marker
Popis BACKGROUND: The aim of the study was to investigate the relationships among (a) glutathione peroxidase (GPx) and malondialdehyde (MDA); (b) oncological characteristics (i.e., TNM classification, tumor grade), and; (c) prognosis of head and neck squamous cell carcinoma. METHODS: In a prospective cohort study, we followed 88 patients for 67.4 months (median 40.3) after surgery for head and neck squamous cell carcinoma. Activity of GPx was determined by ELISA and plasma MDA concentration by liquid chromatography. RESULTS: Lower GPx activity was observed in the T3/4 patients than in the T1/2 group. Tumor grade was significantly correlated with both GPx (P = 0.001) and MDA (P = 0.05, both Spearman). The perioperative level of MDA was higher in patients who later recurred during the follow-up period (n = 15) than in the complete remission group (P = 0.01, Mann-Whitney). Median disease-free interval and overall survival in the group with MDA > median were 29.5 and 32.0 months, respectively, and 38.4 and 40.3 months in the patient group with MDA
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