Clotting factors and eicosanoids protect against nematode infections

• Autoři: HYRŠL Pavel; DOBEŠ Pavel; WANG Zhi; HAULING Thomas; WILHELMSSON Christine; THEOPOLD Ulrich
• Rok publikování: 2011
• Druh: Článek v odborném periodiku
• Časopis / Zdroj: Journal of Innate Immunity
• Fakulta / Pracoviště MU: Přírodovědecká fakulta
• Obor: Imunologie
• Klíčová slova: Drosophila melanogaster; eicosanoids; entomopathogenic nematodes; Heterorhabditis bacteriophora; transglutaminase; coagulation; Photorhabdus luminescens
• Popis: We show that hemolymph clotting protects Drosophila melanogaster against infections with an entomopathogenic nematode and its symbiotic bacterium. We also provide biochemical and genetic evidence for an involvement of eicosanoids in the same infection model. Taken together our results confirm the conserved nature of the immune function of clot formation.

Související projekty

• Vliv inhibitorů biosyntézy eikonsanoidů na imunitu zavíječe voskového Galleria mellonella