Informace o publikaci

The Tubulin-Bound Structure of the Antimitotic Drug Tubulysin

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KUBICEK Karel GRIMM S. Kaspar ORTS Julien SASSE Florenz CARLOMAGNO Teresa

Rok publikování 2010
Druh Článek v odborném periodiku
Časopis / Zdroj Angewandte Chemie International Edition
Fakulta / Pracoviště MU

Přírodovědecká fakulta

Citace
www http://onlinelibrary.wiley.com/doi/10.1002/anie.200906828/abstract
Obor Biofyzika
Klíčová slova conformation analysis;cytotoxicity;microtubules;NMR spectroscopy;tubulysin
Popis Bound to be active: The solution structure of tubulin-bound tubulysin A is determined from transferred NOE data (see picture; blue N, red O, yellow S, green C), and this bioactive conformation is compared to the unbound conformation. The binding site on tubulin is examined on the basis of the interligand NOEs observed between epothilone A and tubulysin A in the presence of tubulin.
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