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Relationship between high aortic pulse pressure and extension of coronary atherosclerosis in males

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PAŘENICA Jiří KALA Petr JARKOVSKÝ Jiří POLOCZEK Martin BOČEK Otakar JEŘÁBEK Petr NEUGEBAUER Petr VYTISKA Miroslav PARENICOVA Ilona TOMCIKOVA D. PÁVKOVÁ GOLDBERGOVÁ Monika ŠPINAR Jindřich

Rok publikování 2011
Druh Článek v odborném periodiku
Časopis / Zdroj Physiological Research
Fakulta / Pracoviště MU

Lékařská fakulta

Citace
Obor Kardiovaskulární nemoci včetně kardiochirurgie
Klíčová slova aortic pulse pressure; coronary atherosclerosis; males
Popis A high pulse pressure (PP) is a marker of increased artery stiffness and represents a well - established independent predictor for cardiovascular morbidity and mortality. The objective of the research was to determine whether invasively measured central aortic PP was related to the presence and severity of coronary artery disease. In total 1075 consecutive stable male patients undergoing diagnostic coronary angiography with a preserved left ventricular function were included. Diseased coronary vessel (DCV) was defined by the presence of > 50% stenosis. Results: Men were divided into 3 groups according to the increased value of PP. The average PP in the tertils was 47.8+-7.1 vs. 67.0+-4.9 vs. 91.3+-12.8 mm Hg (p<0,01). The significant differences of DCV was found among tertils (1.51+-1.11 vs 1.80+-1.04 vs. 1.99+-0.98 DCV, p<0.01). Aortic PP together with age and hyperlipoproteinemia were found as factors with an independent relationship to DCV according to multivariate linear regression. Conclusion: the increased value of aortic PP in the male population is independently connected with more severe atherosclerosis evaluated by the significant number of DCV.
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