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Expression and characterization of c-Myb in prenatal odontogenesis

Název česky Exprese a charakterizace c-Myb v prenatální odontogenezi
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MATALOVÁ Eva BUCHTOVÁ Marcela TUCKER Abigail S BENDER Timothy P JANEČKOVÁ Eva LUNGOVÁ Vlasta BALKOVÁ Simona ŠMARDA Jan

Druh Článek v odborném periodiku
Časopis / Zdroj Development, Growth and Differentiation
Fakulta / Pracoviště MU

Lékařská fakulta Přírodovědecká fakulta

Citace
Doi http://dx.doi.org/10.1111/j.1440-169X.2011.01287.x
Obor Genetika a molekulární biologie
Klíčová slova morphogenesis; mouse; Myb; pig; tooth
Popis The transcription factor c-Myb is involved in the control of cell proliferation, survival and differentiation. As these processes accompany the morphogenesis of developing teeth, this work investigates the possible role of c-Myb during odontogenesis. Analysis of the expression of c-Myb in the monophyodont mouse was followed by similar analysis in a diphyodont species, the pig, which has a dentition more closely resembling that of the human. The distribution of c-Myb was correlated with the pattern of proliferation and apoptosis and the tooth phenotype of c-Myb mutant mice was also assessed. In the mouse, c-Myb expression was detected throughout prenatal development of the first molar tooth. Negative temporospatial correlation was found between c-Myb expression and apoptosis, while c-Myb expression positively correlated with proliferation. c-Myb-positive cells, however, were more abundant than the proliferating cell nuclear antigen positive cells, suggesting other roles of c-Myb in odontogenesis. In the minipig, in contrast to the mouse, there was an asymmetrical arrangement of c-Myb positive cells, with a higher presence on the labial side of the tooth germ and dental lamina. A cluster of negative cells was situated in the mesenchyme close to the tooth bud. At later stages, the number of positive cells decreased and these cells were situated in the upper part of the dental papilla in the areas of future cusp formation. The expression of c-Myb in both species was strong in the odontoblasts and ameloblasts at the stage of dentin and enamel production suggesting a possible novel role of c-Myb during tooth mineralization.
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