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Association of aneuploidy category with centrosome amplification in multiple myeloma

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KRYUKOV Fedor DEMENTYEVA Elena Vladimirovna SMETANA Jan ŠEVČÍKOVÁ Sabina KUGLÍK Petr HÁJEK Roman

Rok publikování 2011
Druh Článek v odborném periodiku
Časopis / Zdroj Leukemia & Lymphoma
Fakulta / Pracoviště MU

Lékařská fakulta

Citace
Doi http://dx.doi.org/10.3109/10428194.2011.587561
Obor Onkologie a hematologie
Klíčová slova multiple myeloma; centrosome amplification; plasma cell; B-cell; hyperdiploid
Popis Multiple myeloma is a lymphoproliferative disease characterized by clonal expansion of neoplastic plasma cells (PCs) within the bone marrow. Although PCs are recognized as fully malignant cells, the exact developmental stage at which malignant transformation occurs is still unknown. Since centrosome abnormalities constitute one of the most important mechanisms implicated in chromosomal instability in cancer, the aim of this study was to investigate a possible association of centrosome amplification in populations of B-cell lineage with specific chromosome aberrations and aneuploidy categories occurring in MM. For this purpose, a total of 140 patients with MM were included in the study. In our study, we showed a correlation between centrosome amplification in B cells and hyperdiploidy in plasma cells. This raises the suspicion of a possible impact of abnormal B cells in myeloma cell development.
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