Informace o publikaci

Genetic polymorphisms and MicroRNAs: new direction in molecular epidemiology of solid cancer

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SLABÝ Ondřej BIENERTOVÁ VAŠKŮ Julie SVOBODA Marek VYZULA Rostislav

Druh Článek v odborném periodiku
Časopis / Zdroj Journal of Cellular and Molecular Medicine
Fakulta / Pracoviště MU

Lékařská fakulta Centrální řídící struktura projektu CEITEC Středoevropský technologický institut

Citace
Doi http://dx.doi.org/10.1111/j.1582-4934.2011.01359.x
Obor Ostatní lékařské obory
Klíčová slova Cancer; Diagnosis; MicroRNA; Polymorphism; Prediction; Prognosis; Risk factor; SNP
Popis MicroRNAs (miRNAs) are small non-coding RNAs which regulate gene expression. Single nucleotide polymorphisms (SNPs) may occur in miRNA biogenesis pathway genes, pri-miRNA, pre-miRNA or a mature miRNA sequence. Such polymorphisms may be functional with respect to biogenesis and actions of mature miRNA. Specific SNPs were identified in predicted miRNA target sites within 3' untranslated regions of mRNAs. These SNPs have a potential to affect the efficiency of miRNA binding to the target sites or can create or disrupt binding sites. Resulting gene dysregulation may involve changes in phenotype and may eventually prove critical for the susceptibility to cancer and its onset as well as for estimates of prognosis and therapy response. In this review, we provide a comprehensive list of potentially functional miRNA-related SNPs and summarize their importance as candidate cancer biomarkers.

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