Genetic polymorphisms and MicroRNAs: new direction in molecular epidemiology of solid cancer

Autoři SLABÝ Ondřej BIENERTOVÁ VAŠKŮ Julie — SVOBODA Marek — VYZULA Rostislav
Druh Článek v odborném periodiku
Citace SLABÝ, Ondřej, Julie BIENERTOVÁ VAŠKŮ, Marek SVOBODA a Rostislav VYZULA. Genetic polymorphisms and MicroRNAs: new direction in molecular epidemiology of solid cancer. Journal of Cellular and Molecular Medicine, 2012, roč. 16, č. 1, s. 8-21. ISSN 1582-1838. doi:10.1111/j.1582-4934.2011.01359.x.
Originální jazyk angličtina
Obor Ostatní lékařské obory
Doi http://dx.doi.org/10.1111/j.1582-4934.2011.01359.x
Klíčová slova Cancer; Diagnosis; MicroRNA; Polymorphism; Prediction; Prognosis; Risk factor; SNP

MicroRNAs (miRNAs) are small non-coding RNAs which regulate gene expression. Single nucleotide polymorphisms (SNPs) may occur in miRNA biogenesis pathway genes, pri-miRNA, pre-miRNA or a mature miRNA sequence. Such polymorphisms may be functional with respect to biogenesis and actions of mature miRNA. Specific SNPs were identified in predicted miRNA target sites within 3' untranslated regions of mRNAs. These SNPs have a potential to affect the efficiency of miRNA binding to the target sites or can create or disrupt binding sites. Resulting gene dysregulation may involve changes in phenotype and may eventually prove critical for the susceptibility to cancer and its onset as well as for estimates of prognosis and therapy response. In this review, we provide a comprehensive list of potentially functional miRNA-related SNPs and summarize their importance as candidate cancer biomarkers.

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