Informace o publikaci

Phosphoinositide 3-kinase inhibition enables retinoic acid-induced neurogenesis in monolayer culture of embryonic stem cells.

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KOTASOVÁ Hana VESELÁ Iva KUČERA Jan HOUDEK Zbyněk PROCHÁZKOVÁ Jiřina KRÁLÍČKOVÁ Milena PACHERNÍK Jiří

Rok publikování 2012
Druh Článek v odborném periodiku
Časopis / Zdroj J Cell Biochem
Fakulta / Pracoviště MU

Přírodovědecká fakulta

Citace
Doi http://dx.doi.org/10.1002/jcb.23380
Obor Fyziologie
Klíčová slova Embryonic stem cell;retionic acid;neurogenesis;differentiation
Popis Retinoic acid is able to induce the differentiation of embryonic stem cells into neuronal lineages. The mechanism of this effect is unknown but it has been evidenced to be dependent on the formation of floating spheroids called embryoid bodies. Results presented here show that the inhibition of phosphoinositide 3-kinase signaling predetermines mouse embryonic stem cells to retinoic acid induced neurogenesis in monolayer culture with no need of embryoid bodies formation.
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