Informace o publikaci

Changes in the expression of FGFR3 in patients with chronic myeloid leukaemia receiving transplants of allogeneic peripheral blood stem cells

Autoři

DVORAKOVA D. KREJČÍ Pavel MAYER Jiří FAJKUS Jiří HAMPL Aleš DVOŘÁK Petr

Rok publikování 2001
Druh Článek v odborném periodiku
Časopis / Zdroj British journal of haematology
Fakulta / Pracoviště MU

Přírodovědecká fakulta

Citace
Doi http://dx.doi.org/10.1046/j.1365-2141.2001.02829.x
Obor Fyziologie
Klíčová slova fibroblast growth factor receptor 3; chronic myeloid leukaemia; stem cell transplantation; BCR/ABL; prognosis
Popis Fibroblast growth factor receptors (FGFR1-4) are implicated in various cellular events, including cell growth and transformation. Here, we showed that patients suffering from chronic myeloid leukaemia (CML) express high levels of FGFR3 mRNA in white blood cells (WBCs). After stem cell transplantation and reconstitution of haematopoiesis, the expression of FGFR3 decreased and was maintained at low levels that are typical of healthy individuals. However, FGFR3 expression became upregulated again in those patients that had accelerated BCR/ABL rearrangement and underwent relapse of leukaemia. Our findings suggest that. in CML, the changing levels of FGFR3 transcripts in WBCs map have prognostic significance.