MicroRNA in renal cell carcinoma – potential marker for prediction of early metastasis after nephrectomy.

• Autoři: RÉDOVÁ Martina; SLABÝ Ondřej; LAKOMÝ Radek; POPRACH Alexandr; HODEK Jan; SVOBODA Marek; RADOVÁ Lenka; FABIAN Pavel; ILIEV Robert; OVESNÁ Jaroslava; MICHÁLEK Jaroslav; VYZULA Rostislav
• Rok publikování: 2011
• Druh: Konferenční abstrakty
• Popis: Renal cell carcinoma (RCC) is the most common neoplasma of the adult kidney accounting for about 3 % of adult malignancies. RCC originates in the lining of the proximal renal tubule. The clear cell histology type, renal clear cell carcinoma (RCCC), is approximately 80-85%) of metastatic RCC and the most frequent subtype of RCC. Although surgigal resection remains the best curative therapy for RCC, after the curative nephrectomy, 20-40% patients will develope recurrence. Moreover, the absence of biomarkers for early detection and follow-up of the disease complicate the on-time diagnosis. For these reasons, it is worth revealing the underlying molecular and genetic mechanisms for RCC initiation and development, and finding new biomarkers which would enable prediction of early metastasis after curative nephrectomy.