MicroRNAs and Glioblastoma

Autoři ŠÁNA Jiří LAKOMÝ Radek HAJDÚCH Marian SLABÝ Ondřej
Druh Kapitola v knize
Citace ŠÁNA, Jiří, Radek LAKOMÝ, Marian HAJDÚCH a Ondřej SLABÝ. MicroRNAs and Glioblastoma. In Ondrej Slaby. MicroRNAs in Solid Cancer: From Biomarkers to Therapeutic Targets. New York: Nova Science Publishers, Inc., 2012. s. 169-176, 8 s. ISBN 978-1-61324-514-9.
Originální jazyk angličtina
Obor Onkologie a hematologie
Klíčová slova microRNAs; glioblastoma

Glioblastoma is the highly malignant brain tumor with very poor prognosis. Despite great progress, current therapeutic approaches are insufficient for total cure of patients afflicted with this malignity. MiRNAs represent promising therapeutic targets in glioblastoma. In this chapter we summarize the current knowledge about miRNAs significance in glioblastoma, with special focus on their involvement in core signaling pathways, their roles in drug resistance and potential clinical implications.

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