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Flow Based Enumeration of Plasmablasts in Peripheral Blood After Vaccination as a Novel Diagnostic Marker for Assessing Antibody Responses in Patients with Hypogammaglobulinaemia

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THON Vojtěch VLKOVÁ Marcela CHOVANCOVÁ Zita LITZMAN Jiří LOKAJ Jindřich

Rok publikování 2012
Druh Kapitola v knize
Fakulta / Pracoviště MU

Lékařská fakulta

Citace
Popis Hypogammaglobulinaemic patients are often started on immunoglobulin substitution therapy before antibody production is adequately evaluated. In such a situation, it is difficult to segregate transferred from antigen-induced specific antibody. Therefore we characterized changes in B-cell subpopulations in hypogammaglobulinaemic patients, including plasmablasts, in peripheral blood by flow cytometry after in vivo antigen challenge. We investigated the specificity of antibody production on the B-cell level by ELISPOT, which is independent of substitution therapy.
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