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Matrix metalloproteinase 13 genotype in rs640198 polymorphism is associated with severe coronary artery disease

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VAŠKŮ Anna MELUZÍN Jaroslav BLAHÁK Jiří KINCL Vladimír PÁVKOVÁ GOLDBERGOVÁ Monika SITAR Jan ZLÁMAL Filip BIENERTOVÁ VAŠKŮ Julie VÍTOVEC Jiří

Rok publikování 2012
Druh Článek v odborném periodiku
Časopis / Zdroj DISEASE MARKERS
Fakulta / Pracoviště MU

Lékařská fakulta

Citace
Doi http://dx.doi.org/10.3233/DMA-2012-0902
Obor Mikrobiologie, virologie
Klíčová slova MMP-13; CAD; rs640198; severity
Popis Atherosclerosis as a main etiopathogenetic source for coronary artery disease (CAD) development is intimately related to dynamic changes in the extracellular matrix (ECM). Elevated levels of MMP-13 have been observed in human atherosclerotic plaques which could also involve variability in MMP-13 gene. The aim of the study was to associate rs640198 polymorphism with CAD and/or with its severity. The study comprised 1071 consecutive patients with suspected or known coronary artery disease (CAD), confirmed by coronary angiography. Genotyping for the rs640198 polymorphism in MMP-13 gene was performed using Taqman (R) assay. The TT and TG genotypes of rs640198 polymorphism in MMP-13 gene confer the significantly increased risk of triple vessel disease compared to patients without atherosclerotic lesions in coronary arteries (odds ratio = 1.64, Pcorr = 0.05). Furthermore, an increased risk of having 5 and more stenoses (odds ratio = 1.90, Pcorr = 0.004) was observed in TT and TG carriers (sensitivity of 0.613 and a specificity of 0.544; power of the test is 0.87). The T allele of MMP-13 intron polymorphism rs640198 is associated with the severity of coronary artery disease, represented by the number of affected arteries as well as by the number of stenoses confirmed by coronarography.
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