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Modulatory Effects of Eschscholzia californica Alkaloids on Recombinant GABAA Receptors

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FEDURCO Milan GREGOROVÁ Jana ŠEBRLOVÁ Kristýna KANTOROVÁ Jana PEŠ Ondřej BAUR Roland SIGEL Erwin TÁBORSKÁ Eva

Rok publikování 2015
Druh Článek v odborném periodiku
Časopis / Zdroj Biochemistry Research International
Fakulta / Pracoviště MU

Lékařská fakulta

Citace
Doi http://dx.doi.org/10.1155/2015/617620
Obor Biochemie
Klíčová slova Escholzia californica; alkaloids; gaba receptors; mass spectrometry
Popis The California poppy (Eschscholzia californica Cham.) contains a variety of natural compounds including several alkaloids found exclusively in this plant. Because of the sedative, anxiolytic, and analgesic effects, this herb is currently sold in pharmacies in many countries. However, our understanding of these biological effects at the molecular level is still lacking. Alkaloids detected in E. californica could be hypothesized to act at GABAA receptors, which are widely expressed in the brain mainly at the inhibitory interneurons.

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