Publication details

Modulatory Effects of Eschscholzia californica Alkaloids on Recombinant GABAA Receptors

Authors

FEDURCO Milan GREGOROVÁ Jana ŠEBRLOVÁ Kristýna KANTOROVÁ Jana PEŠ Ondřej BAUR Roland SIGEL Erwin TÁBORSKÁ Eva

Year of publication 2015
Type Article in Periodical
Magazine / Source Biochemistry Research International
MU Faculty or unit

Faculty of Medicine

Citation
Doi http://dx.doi.org/10.1155/2015/617620
Field Biochemistry
Keywords Escholzia californica; alkaloids; gaba receptors; mass spectrometry
Description The California poppy (Eschscholzia californica Cham.) contains a variety of natural compounds including several alkaloids found exclusively in this plant. Because of the sedative, anxiolytic, and analgesic effects, this herb is currently sold in pharmacies in many countries. However, our understanding of these biological effects at the molecular level is still lacking. Alkaloids detected in E. californica could be hypothesized to act at GABAA receptors, which are widely expressed in the brain mainly at the inhibitory interneurons.

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