Ing. RNDr. Martin Marek, Ph.D., MBA
Head, Structural Biology
Correspondence Address:
Kotlářská 267/2, 611 37 Brno
Office: bldg. C13/308
Kamenice 753/5
625 00 Brno
Phone: | +420 549 49 8763 |
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E‑mail: |
Total number of publications: 30
2021
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The structure of the mouse ADAT2/ADAT3 complex reveals the molecular basis for mammalian tRNA wobble adenosine-to-inosine deamination
Nucleic acids research, year: 2021, volume: 49, edition: 11, DOI
2020
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Decoding the intricate network of molecular interactions of a hyperstable engineered biocatalyst
Chemical Science, year: 2020, volume: 11, edition: 41, DOI
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Structural and catalytic effects of surface loop-helix transplantation within haloalkane dehalogenase family
Computational and Structural Biotechnology Journal, year: 2020, volume: 18, edition: December 2020, DOI
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Structures of hyperstable ancestral haloalkane dehalogenases show restricted conformational dynamics
Computational and Structural Biotechnology Journal, year: 2020, volume: 18, edition: 2020, DOI
2019
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Functional switching based on altered enzyme flexibility via InDel mutagenesis of a reconstructed ancestor
Year: 2019, type: Conference abstract
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Light-Emitting Dehalogenases: Reconstruction of Multifunctional Biocatalysts
ACS Catalysis, year: 2019, volume: 9, edition: 6, DOI
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One-Atom Substitution Enables Direct and Continuous Monitoring of Histone Deacylase Activity
Biochemistry, year: 2019, volume: 58, edition: 48, DOI
2018
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A Novel Class of Schistosoma mansoni Histone Deacetylase 8 (HDAC8) Inhibitors Identified by Structure-Based Virtual Screening and In Vitro Testing
Molecules, year: 2018, volume: 23, edition: 3, DOI
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Characterization of Histone Deacetylase 8 (HDAC8) Selective Inhibition Reveals Specific Active Site Structural and Functional Determinants
Journal of Medicinal Chemistry, year: 2018, volume: 61, edition: 22, DOI
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Isoform-selective HDAC1/16/8 inhibitors with an imidazo-ketopiperazine cap containing stereochemical diversity
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, year: 2018, volume: 373, edition: 1748, DOI