Project information
Activation of adenosine receptors combined with cyclooxygenase inhibition in modulation of radiation-induced myelosuppression
- Project Identification
- GA305/08/0158
- Project Period
- 1/2008 - 12/2008
- Investor / Pogramme / Project type
-
Czech Science Foundation
- Standard Projects
- MU Faculty or unit
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Faculty of Medicine
- doc. RNDr. Vladimír Znojil, CSc.
- Keywords
- adenosine receptor agonistsa, cyclooxygenase inhibition, radiation-induced bone marrow damage
- Cooperating Organization
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Institute of Biophysics
- Responsible person doc. MUDr. Michal Hofer, CSc.
Hitherto performed studies of the applicants of this project have demonstrated the effectiveness of two original experimantal pharmacological approaches aimed at stimulation of regeneration of hematopoiesis supressed by exposure of a mammalian organism to ionizing radiation.
Publications
Total number of publications: 4
2014
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Agonist of the adenosine A(3) receptor, IB-MECA, and inhibitor of cyclooxygenase-2, meloxicam, given alone or in a combination early after total body irradiation enhance survival of gamma-irradiated mice
Radiation and Environmental Biophysics, year: 2014, volume: 53, edition: 1, DOI
2011
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A Single Dose of an Inhibitor of Cyclooxygenase 2, Meloxicam, Administered Shortly after Irradiation Increases Survival of Lethally Irradiated Mice
Radiation Research, year: 2011, volume: 176, edition: 2, DOI
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Expression of mRNA for Adenosine A1, A2a, A2b, and A3 Receptors in HL-60 Cells: Dependence on Cell Cycle Phases
Physiological Research, year: 2011, volume: 60, edition: 6
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Inhibition of cyclooxygenase-2 promotes the stimulatory action of adenosine A3 receptor agonist on hematopoiesis in sublethally y-irradiated mice
Biomedicine & Pharmacotherapy, year: 2011, volume: 65, edition: 6, DOI