Project information
Czech Infrastructure for Integrative Structural Biology
(CIISB)
- Project Identification
- LM2018127
- Project Period
- 1/2020 - 12/2022
- Investor / Pogramme / Project type
-
Ministry of Education, Youth and Sports of the CR
- Large Infrastructures for Research, Development and Innovation
- MU Faculty or unit
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Central European Institute of Technology
- prof. RNDr. Vladimír Sklenář, DrSc.
- Cooperating Organization
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Institute of Biotechnology CAS
The Czech Infrastructure for Integrative Structural Biology (CIISB) is a distributed infrastructure of the core facilities and central laboratories of CEITEC (Central European Institute of Technology, Brno) and BIOCEV (Biotechnology and Biomedicine Centre, Vestec) providing expertise and access to technologies used for integrative approaches to structural analysis of biologically important cellular components and macromolecules - proteins, nucleic acids, and their complexes. CIISB, equipped with the cutting-edge technologies, will offer access to the equipment and expertise in the following fields: high-field NMR spectroscopy; high throughput crystallization of biological macromolecules; X-ray diffraction techniques; Bio-SAXS measurements; AFM imaging; characterization of proteins, nucleic acids and complexes by biophysical methods including microcalorimetry, dynamic light scattering, and surface plasmon resonance; high-end cryo-electron microscopy and tomography allowing studies of cellular structures, organelles, and biomacromolecular complexes by 3D imaging; protein expression in eukaryotic cells; high-end mass spectrometry characterization of biomacromolecules; determination of protein post-translational modifications; MS-based peptide mapping/sequencing; high throughput sequencing and proteomic services. CIISB infrastructure aims to provide a high quality open access services in provision of methods and techniques on a level of national and trans-national importance. CIISB is a part of the ESFRI project INSTRUCT-ERIC.
Sustainable Development Goals
Masaryk University is committed to the UN Sustainable Development Goals, which aim to improve the conditions and quality of life on our planet by 2030.
Publications
Total number of publications: 327
2021
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Synthesis of high surface area aluminophosphate and -phosphonate xerogels by non-hydrolytic sol-gel reactions
Microporous and Mesoporous Materials, year: 2021, volume: 311, edition: February 2021, DOI
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Synthesis of Tetravalent Thio- and Selenogalactoside-Presenting Galactoclusters and Their Interactions with Bacterial Lectin PA-IL from Pseudomonas aeruginosa
Molecules, year: 2021, volume: 26, edition: 3, DOI
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The comprehensive interactomes of human adenosine RNA methyltransferases and demethylases reveal distinct functional and regulatory features
Nucleic acids research, year: 2021, volume: 49, edition: 19, DOI
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The oligomeric states of elicitins affect the hypersensitive response and resistance in tobacco
Journal of Experimental Botany, year: 2021, volume: 72, edition: 8, DOI
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The yeast mitochondrial succinylome: Implications for regulation of mitochondrial nucleoids
The Journal of Biological Chemistry, year: 2021, volume: 297, edition: 4, DOI
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Thick nanoporous matrices of polystyrene nanoparticles and their potential for electrochemical biosensing
Electrochimica Acta, year: 2021, volume: 368, edition: FEB, DOI
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TIME-LAPSE MONITORING OF CELL MECHANICAL PROPERTIES
CONFERENCE PROCEEDINGS - NANOCON 2020, year: 2021
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Towards Profiling of the G-Quadruplex Targeting Drugs in the Living Human Cells Using NMR Spectroscopy
International Journal of Molecular Sciences, year: 2021, volume: 22, edition: 11, DOI
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Towards spruce-type photosystem II: consequences of the loss of light-harvesting proteins LHCB3 and LHCB6 in Arabidopsis
Plant Physiology, year: 2021, volume: 187, edition: 4, DOI
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Trimethylacetic Anhydride-Based Derivatization Facilitates Quantification of Histone Marks at the MS1 Level
Molecular and Cellurar Proteomic, year: 2021, volume: 20, edition: JAN 01, DOI