Project information
National Center for Medical Genomics
(NCLG)
- Project Identification
- LM2018132
- Project Period
- 1/2020 - 12/2022
- Investor / Pogramme / Project type
-
Ministry of Education, Youth and Sports of the CR
- Large Infrastructures for Research, Development and Innovation
- MU Faculty or unit
- Central European Institute of Technology
- Cooperating Organization
-
Charles University
- Responsible person prof. Ing. Stanislav Kmoch, CSc.
National Centre of Medical Genomics (NCMG) is the only research infrastructure in the Roadmap for Large Research, Development and Innovation Infrastructures of the Czech Republic focused on medical genomics. Local (national) genomic infrastructure is the only way how we can unite genomic experts, clinicians, scientist, patients and industry to study, identify and understand causes of individual and population specific diseases. Interdisciplinary collaboration will increase competitiveness of Czech biomedical science and our recent results clearly document, that this approach leads to significant discoveries (e.g. identification of causal genes and elucidation of molecular basis of > 20 human genetic diseases, leukemia, aspergillosis, inherited neurodegenerative and neuromuscular diseases, skin diseases and metabolics diseases), may attract foreign investigators to use the expertize and may have economic impact (new diagnostic products introduced on the market thanks to collaboration of MU and company Generi BioTech). Infrastructure is also important for education and training of new generation of scientists, computing specialists, bioinformaticians, statisticians, instrument operators, clinical genomicists and clinicians. All participating groups are involved in pregraduate and postgraduate education as well as in organization of specialised training programs and courses and organisation of workshops and symposia.
Sustainable Development Goals
Masaryk University is committed to the UN Sustainable Development Goals, which aim to improve the conditions and quality of life on our planet by 2030.
Publications
Total number of publications: 72
2022
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Evolution of TP53 abnormalities during CLL disease course is associated with telomere length changes
BMC Cancer, year: 2022, volume: 22, edition: 1, DOI
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Generation and maturation of human iPSC-derived 3D organotypic cardiac microtissues in long-term culture
Nature Scientific Reports, year: 2022, volume: 12, edition: 1, DOI
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Global Transcriptomic Analysis of Bacteriophage-Host Interactions between a Kayvirus Therapeutic Phage and Staphylococcus aureus
Microbiology Spectrum, year: 2022, volume: 10, edition: 3, DOI
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Gut-content analysis in four species, combined with comparative analysis of trophic traits, suggests an araneophagous habit for the entire family Palpimanidae (Araneae)
Organisms Diversity & Evolution, year: 2022, volume: 22, edition: 1, DOI
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HLA-E and HLA-F Are Overexpressed in Glioblastoma and HLA-E Increased After Exposure to Ionizing Radiation
CANCER GENOMICS & PROTEOMICS, year: 2022, volume: 19, edition: 2, DOI
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KMT2C methyltransferase domain regulated INK4A expression suppresses prostate cancer metastasis
Molecular Cancer, year: 2022, volume: 21, edition: 1, DOI
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LncRNA PVT1 is increased in renal cell carcinoma and affects viability and migration in vitro
JOURNAL OF CLINICAL LABORATORY ANALYSIS, year: 2022, volume: 36, edition: 6, DOI
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Long read targeted sequencing enables genomic analysis of translocation hotspots in lymphoproliferative diseases
Year: 2022, type: Conference abstract
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Lyn Phosphorylates and Controls ROR1 Surface Dynamics During Chemotaxis of CLL Cells
Frontiers in Cell and Developmental Biology, year: 2022, volume: 10, edition: February 2022, DOI
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Mendel Genetics Conference 2022: Tours at CEITEC
Year: 2022, type: Popularization text