Publication details

NKT-like Cells are Expanded in Solid Tumour Patients

Authors

ZDRAŽILOVÁ DUBSKÁ Lenka VALÍK Dalibor BUDINSKÁ Eva FRGALA Tomáš BAČÍKOVÁ Libuše DEMLOVÁ Regina

Year of publication 2012
Type Article in Periodical
Magazine / Source Klinická onkologie
MU Faculty or unit

Faculty of Medicine

Citation
Field Oncology and hematology
Keywords NKT like cells; cancer; CD3+ CD56+ cells; flow cytometry; breast neoplasms
Description CD3+ CD56+ NKT-like cells have been shown to produce substantial amounts of pro-inflammatory cytokines and to mediate lysis of malignant cells. Using flow cytometry, we evaluated the absolute NKT-like cell count in peripheral blood from individuals in a reference population and the median number was 0.085 . 109/l. The average number of NKT-like cells in patients with disseminated cancer was 2.65 fold higher than in the reference population. The number of CD3+ CD56+ cells in solid tumour patients who achieved complete remission was comparable to the reference population. In breast cancer patients with initially (prior to therapy) increased number of NKT-like cells, we observed a trend toward longer disease-free survival. Thus we conclude that CD3+ CD56+ NKT-like cells have potential to suppress tumour evasion and are expanded in peripheral blood of some epithelial tumour patients.

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