Publication details

MicroRNAs involved in skeletal muscle development and their roles in rhabdomyosarcoma pathogenesis

Authors

NOVÁK Jan VINKLÁREK Jan BIENERTOVÁ VAŠKŮ Julie SLABÝ Ondřej

Year of publication 2013
Type Article in Periodical
Magazine / Source PEDIATRIC BLOOD & CANCER
MU Faculty or unit

Faculty of Medicine

Citation
Web http://onlinelibrary.wiley.com/doi/10.1002/pbc.24664/pdf
Doi http://dx.doi.org/10.1002/pbc.24664
Field Physiology
Keywords microRNA; myogenesis; myomirs; rhabdomyosarcoma
Attached files
Description MicroRNAs (miRs) are small non-coding RNAs known to fulfill various functions in tissue development, function, and pathogenesis of various diseases, including cancer. Rhabdomyosarcoma (RMS) represents the most common soft tissue tumor in the pediatric population. miRs have been shown to play important roles in RMS pathogenesis and some of the studies suggest their potential as diagnostic, prognostic, and even therapeutic tools facilitating better management of this disease. This review summarizes current information about the role of miRs in the development of normal skeletal muscle and their deregulation in RMS.

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