Publication details

The PER3 VNTR polymorphism is a predictor of dietary composition in the Central European population

Authors

BIENERTOVÁ VAŠKŮ Julie NOVÁK Jan ZLÁMAL Filip LIPKOVÁ Jolana ŠŤASTNÝ Jiří FOREJT Martin JACKOWSKÁ Aneta VAŠKŮ Anna

Year of publication 2014
Type Article in Periodical
Magazine / Source Biological Rhythm Research
MU Faculty or unit

Faculty of Medicine

Citation
Doi http://dx.doi.org/10.1080/09291016.2014.913949
Field Physiology
Keywords PER3; VNTR polymorphism; dietary composition; sleep
Attached files
Description Objectives, design: The aim of this case control study was to investigate possible associations of the variable number tandem-repeat (VNTR) polymorphism in the PER3 gene with obesity-related anthropometric traits, sleep and nutritional behaviour. Setting: A total of 329 volunteers of the Czech Caucasian origin were enrolled in the study. The allele-specific PCR-based method was used to determine the VNTR PER3 genotypes, dietary composition and time patterns were evaluated using seven day native food records and seven day sleep records. Results: No differences were observed in allele frequencies between the obese and the non-obese individuals. The PER3 VNTR polymorphism was associated with the total daily energy derived from carbohydrates (p < 0.01) and fat (p < 0.02). No association with sleep homeostasis was observed. Conclusions: We have demonstrated the relationship between the PER3 VNTR polymorphism and behavioural patterns of the food intake in the Central-European population.

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